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KMID : 0385020010170010047
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Korean Journal of Laboratory Animal Science
2001 Volume.17 No. 1 p.47 ~ p.58
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Historical control data for developmental toxicity study in new Zealand White rabbits
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정문구/Chung, Moon Koo
김종춘/배주현/김일환/한상섭/Kim, Jong Choon/Bae, Joo Hyun Bae/Kim, II Hwan/Han, Sang Seop
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Abstract
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The background control data were compiled from rabbit developmental toxicity studies conducted at Toxicology Research Center, KRICT during the 1993-1999 period. These data were assembled in order to provide background information for the maternal and fetal data collected in 9 developmental toxicity studies using New Zealand White rabbits. A total of 167 inseminated females were used in these studies during the seven-year period and overall pregnancy rate of these females was 84.4%. The pregnancy rate of artificially inseminated females was slightly (13%) higher than that of naturally mated females. The present background control data included body weights, food consumption, hematological values and organ weights of pregnant females, caesarean section data, and fetal examination data. These data can be used not only as a historical database for the meaningful interpretation of data from reproductive and developmental toxicity studies, but also as a contribution to biological characterization of New Zealand White rabbits.
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KEYWORD
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